# London Kidney Clinical Research

> London Kidney Clinical Research conducts clinical studies and observational research to improve outcomes for patients with kidney disease. Affiliated with We...

## Topics
- Observational Study
- Administrative Data
- Chronic Kidney Disease
- Hemodialysis
- Health Systems
- Risk Estimation and Prognosis
- Kidney Transplantation
- Cardiovascular Disease
- Drug Safety
- Perioperative and Surgery

## Publication Topics
- Observational Study
- Administrative Data
- Chronic Kidney Disease
- Hemodialysis
- Health Systems
- Risk Estimation and Prognosis
- Kidney Transplantation
- Cardiovascular Disease
- Drug Safety
- Interventional Study
- Perioperative and Surgery
- Acute Kidney Injury
- Genetic Kidney Disease
- Innovation in Study Design or Analysis
- Narrative Review

## Key Pages
- [Active Studies](https://londonkidney.ca/trials)
- [Publications](https://londonkidney.ca/publications)
- [Team](https://londonkidney.ca/team)
- [News](https://londonkidney.ca/news)
- [Subscribe for updates](https://londonkidney.ca/updates)
- [Contact us](https://londonkidney.ca/contact)
- [Opportunities](https://londonkidney.ca/training)
- [Capabilities (sponsors and partners)](https://londonkidney.ca/capabilities)

## Markdown
- Home: https://londonkidney.ca/index.html.md
- Active Studies: https://londonkidney.ca/trials.md
- Publications: https://londonkidney.ca/publications.md
- Team: https://londonkidney.ca/team.md
- News: https://londonkidney.ca/news.md
- Subscribe for updates: https://londonkidney.ca/updates.md
- Contact us: https://londonkidney.ca/contact.md
- Opportunities: https://londonkidney.ca/training.md
- Capabilities (sponsors and partners): https://londonkidney.ca/capabilities.md
- Trial details: https://londonkidney.ca/trials/{slug}.md
- Team profiles: https://londonkidney.ca/team/{slug}.md
- News posts: https://londonkidney.ca/news/{slug}.md

## Recent Publication Summaries
- [Impact of COVID-19 on Recipients of Solid Organ Transplants: A Cohort Study of In-Hospital Outcomes From the Canadian Organ Replacement Register. (2026)](https://pubmed.ncbi.nlm.nih.gov/41924193/) — Researchers analyzed national data from Canada to determine how hospital outcomes for organ transplant recipients varied by organ type during the COVID-19 pandemic. The study found that lung transplant recipients faced the highest risks... Topics: Kidney Transplantation, Health Systems, Observational Study, Administrative Data
- [Genetic testing in kidney transplantation and living kidney donor risk assessment. (2026)](https://pubmed.ncbi.nlm.nih.gov/41903706/) — Researchers used genetic testing to identify the underlying cause of kidney failure in nearly one-quarter of transplant recipients, often leading to a reclassification of their original diagnosis. The study also found that while only fou... Topics: Kidney Transplantation, Genetic Kidney Disease, Observational Study, Genomics / Genetic Testing
- [Objective and subjective measures of sleep quality in patients with end stage kidney disease: A cross-sectional study. (2026)](https://pubmed.ncbi.nlm.nih.gov/41880883/) — Researchers evaluated sleep quality in patients with end-stage kidney disease across four Canadian hospitals using both wearable fitness trackers and self-reported questionnaires. The study found that approximately two-thirds of patients... Topics: Chronic Kidney Disease, Hemodialysis, Remote Monitoring and Care, Observational Study, Survey Research, Patient-Reported Outcomes
- [Progressive White Matter Injury Dominates in Patients Receiving Hemodialysis Over Peritoneal Dialysis After One Year of Dialysis. (2026)](https://pubmed.ncbi.nlm.nih.gov/41854748/) — This study compared brain health between patients using different types of dialysis by tracking changes in the brain's white matter over one year. Researchers found that patients receiving hemodialysis experienced more significant and pr... Topics: Hemodialysis, Peritoneal Dialysis, Observational Study, Advanced Imaging
- [Effect of a Change in the Eligibility Criteria for Multidisciplinary Kidney Care. (2026)](https://pubmed.ncbi.nlm.nih.gov/41854725/) — Researchers evaluated the impact of changing the eligibility rules for multidisciplinary kidney care in Ontario, Canada, which shifted from a simple kidney function threshold to a risk-based model. While the change led to fewer patients... Topics: Chronic Kidney Disease, Health Systems, Observational Study, Administrative Data, Innovation in Study Design or Analysis
- [Valve Replacement With Decellularized Homografts may Impede Solid Organ Transplantation. (2026)](https://pubmed.ncbi.nlm.nih.gov/41842831/) — This report describes a case where a patient who received a decellularized heart valve transplant developed high levels of antibodies that could complicate future organ transplants. These findings suggest that even processed tissue graft... Topics: Kidney Transplantation, Cardiovascular Disease, Case Report / Case Series
- [Visceral adipose tissue is associated with changes in leptin, FGF-23 and vitamin D metabolism in chronic kidney disease. (2026)](https://pubmed.ncbi.nlm.nih.gov/41834101/) — Researchers tracked changes in body fat and hormone levels over one year in patients receiving hemodialysis to understand how fat tissue affects bone health. They found that an increase in fat around the internal organs was associated wi... Topics: Hemodialysis, Obesity, Bone Health, Observational Study, Advanced Imaging, Biomarker Development or Validation
- [Long-Term Risk of Major Coronary Artery Disease Events After Thrombotic Microangiopathy Treated With Plasma Exchange. (2026)](https://pubmed.ncbi.nlm.nih.gov/41803631/) — A long-term study in Ontario, Canada, found that adults who survived an episode of thrombotic microangiopathy and achieved remission after plasma exchange had a twofold higher risk of major coronary artery disease events compared to the... Topics: Cardiovascular Disease, Kidney Transplantation, Observational Study, Administrative Data, Risk Estimation and Prognosis
- [Peritoneal dialysis patients exhibit cognitive deficits but not ischemic brain injury: A magnetic resonance spectroscopy & diffusion tensor imaging study. (2026)](https://pubmed.ncbi.nlm.nih.gov/41796443/) — This study used advanced brain imaging and cognitive testing to examine how peritoneal dialysis affects the brain compared to the known risks of hemodialysis. Researchers found that while patients on peritoneal dialysis experienced signi... Topics: Peritoneal Dialysis, Observational Study, Advanced Imaging
- [In adults with severe metabolic acidosis and moderate to severe AKI, IV sodium bicarbonate did not reduce mortality at 90 d. (2026)](https://pubmed.ncbi.nlm.nih.gov/41771120/) — This study examined whether giving intravenous sodium bicarbonate to adults with severe metabolic acidosis and moderate to severe acute kidney injury would improve survival. Researchers found that the treatment did not reduce the risk of... Topics: Acute Kidney Injury, Chronic Kidney Disease, Interventional Study
- [Association of Kidney Volume With Patient-Reported Outcomes in ADPKD. (2026)](https://pubmed.ncbi.nlm.nih.gov/41767623/) — Researchers studied over 450 patients with autosomal dominant polycystic kidney disease to determine how kidney size, kidney function, and pain affect quality of life. The study found that larger kidney volume is associated with poorer p... Topics: Genetic Kidney Disease, Chronic Kidney Disease, Observational Study, Patient-Reported Outcomes, Risk Estimation and Prognosis
- [Statistical analysis of Likert-based ordinal scales: a guide for clinical trialists. (2026)](https://pubmed.ncbi.nlm.nih.gov/41723363/) — This guide for clinical researchers compares different statistical methods for analyzing patient-reported data collected through Likert scales, such as those measuring physical discomfort. Using data from a large hemodialysis trial, rese... Topics: Hemodialysis, Health Systems, Observational Study, Innovation in Study Design or Analysis, Patient-Reported Outcomes
- [Development of a Mortality Risk Prediction Tool for People With Kidney Failure: A Nominal Group Technique Study of End-User Priorities. (2026)](https://pubmed.ncbi.nlm.nih.gov/41722887/) — Researchers conducted a workshop with patients, caregivers, and healthcare providers to determine what features are most important for a tool that predicts the risk of death in people with kidney failure. Participants emphasized that suc... Topics: Chronic Kidney Disease, Health Systems, Education, Observational Study, Qualitative Study, Risk Estimation and Prognosis
- [The Canadian Anatomic Kidney Score: Assessment of reproducibility among surgeons and trainees across Canada. (2026)](https://pubmed.ncbi.nlm.nih.gov/41701884/) — Researchers evaluated the reliability of the Canadian Anatomic Kidney Score, a tool used to assess the quality of donor kidneys before transplantation. By having surgeons and trainees across Canada score images of donor kidneys, the stud... Topics: Kidney Transplantation, Education, Observational Study, Survey Research, Diagnostic Accuracy
- [Adenosine deaminase acting on RNA 1 and receptor-interacting serine/threonine-protein kinase-1 orchestrate the Z-DNA-binding protein 1-mediated PANoptosis and mouse heart transplant rejection. (2026)](https://pubmed.ncbi.nlm.nih.gov/41692363/) — Researchers discovered that a specific protein complex and a cell death process called PANoptosis play a critical role in how the body rejects heart transplants. In mouse models, blocking the protein ZBP1 reduced heart graft injury and i... Topics: Kidney Transplantation, Cardiovascular Disease, Observational Study, Preclinical
- [Methods Article for a Study Protocol: Study Design and Baseline Characteristics of the Treatment of Cardiovascular Disease with Low Dose Rivaroxaban in Advanced Chronic Kidney Disease (TRACK) Trial. (2026)](https://pubmed.ncbi.nlm.nih.gov/41662295/) — This article describes the protocol for an ongoing clinical trial investigating whether low-dose rivaroxaban, an anticoagulant medication, can reduce the risk of heart attack, stroke, and cardiovascular death in patients with advanced ch... Topics: Chronic Kidney Disease, Hemodialysis, Cardiovascular Disease, Drug Safety, Interventional Study
- [Positive B cell flow cytometry crossmatch without detectable donor-specific antibodies: true or false reactivity? (2026)](https://pubmed.ncbi.nlm.nih.gov/41660611/) — This study examined three cases where kidney transplant testing showed a positive crossmatch for B cells despite no detectable antibodies against the donor's tissue type. By using multiple advanced testing methods, researchers found that... Topics: Kidney Transplantation, Case Report / Case Series, Diagnostic Accuracy
- [Team-based care within community health centres in Ontario, Canada and the association with emergency department visits: a population-based retrospective study. (2026)](https://pubmed.ncbi.nlm.nih.gov/41652370/) — This study examined whether receiving care from a multidisciplinary team at community health centres in Ontario, Canada, was linked to a reduction in emergency department visits. Researchers found that while nearly half of patients acces... Topics: Health Systems, Observational Study, Administrative Data
- [Increasing Access to Living Donor Kidney Transplantation: A Program Report. (2026)](https://pubmed.ncbi.nlm.nih.gov/41641402/) — The Living Donor Kidney Transplantation project in Canada is implementing and evaluating several evidence-based strategies to improve access to kidney transplants from living donors. These initiatives include a national consensus on dono... Topics: Kidney Transplantation, Health Systems, Observational Study, Qualitative Study, Administrative Data, Survey Research
- [Cumulative exposure to tacrolimus is associated with increased risk of malignancy for solid organ transplant recipients. (2026)](https://pubmed.ncbi.nlm.nih.gov/41607022/) — A study of over 5,000 transplant recipients in Ontario found that higher cumulative exposure to the immunosuppressant drug tacrolimus is linked to an increased risk of developing new cancers. Patients with the highest levels of the drug... Topics: Kidney Transplantation, Kidney Disease in Cancer, Drug Safety, Drug Dosing and Metabolism, Observational Study, Administrative Data
- [Mass Spectrometry-Based Metabolomics in Pediatric Health and Disease. (2026)](https://pubmed.ncbi.nlm.nih.gov/41590657/) — This review explores how mass spectrometry-based metabolomics can analyze small biological samples to improve the diagnosis and monitoring of various pediatric conditions, including inherited metabolic disorders and cancers. By integrati... Topics: Genetic Kidney Disease, Kidney Disease in Cancer, Diabetes and Metabolism, Narrative Review, Biomarker Development or Validation, Machine Learning / AI
- [Caution in extending SGLT2 inhibitor trials to children with CAKUT: a call for phenotype-specific safety considerations. (2026)](https://pubmed.ncbi.nlm.nih.gov/41571840/) — This commentary highlights the need for caution when applying findings from sodium-glucose cotransporter-2 inhibitor trials to children with congenital anomalies of the kidney and urinary tract. It emphasizes that safety considerations m... Topics: Diabetes and Metabolism, Genetic Kidney Disease, Drug Safety, Commentary / Editorial
- [Endothelial injury to cognitive decline: a 12-month follow-up using computed tomography perfusion and diffusion magnetic resonance imaging in immune-mediated thrombotic thrombocytopenic purpura. (2026)](https://pubmed.ncbi.nlm.nih.gov/41564973/) — Researchers followed 22 survivors of a rare blood disorder called immune-mediated thrombotic thrombocytopenic purpura for one year to understand why many experience long-term memory and thinking problems. The study found that even after... Topics: Cardiovascular Disease, Observational Study, Advanced Imaging
- [Randomized Controlled Trial of Intradialytic Cycling as Kidney Exercise Rehabilitation for Cardiac Stunning in Hemodialysis (TICKERS_HD): A Clinical Research Protocol. (2026)](https://pubmed.ncbi.nlm.nih.gov/41555861/) — This protocol describes an ongoing randomized controlled trial investigating whether 12 weeks of cycling during hemodialysis sessions can reduce heart muscle stress and injury, known as myocardial stunning. Researchers will use ultrasoun... Topics: Hemodialysis, Cardiovascular Disease, Interventional Study, Patient-Reported Outcomes
- [Practice patterns and outcomes in cancer patients developing immune checkpoint inhibitors-related AKI. (2026)](https://pubmed.ncbi.nlm.nih.gov/41014247/) — In this population-based study of over 16,000 cancer patients in Ontario, researchers found that nearly one-third of patients receiving immune checkpoint inhibitors developed acute kidney injury within four years, though the risk was act... Topics: Kidney Disease in Cancer, Acute Kidney Injury, Drug Safety, Observational Study, Administrative Data
- [Insult to Injury: Dialysis-Induced Cerebrovascular Reactivity and Cognitive Impairment. (2025)](https://pubmed.ncbi.nlm.nih.gov/41746790/) — This publication explores how the hemodialysis process may cause repeated injury to the brain by affecting how blood vessels respond to changes in blood flow. These vascular changes are linked to the development of cognitive impairment i...
- [Dialyzer characteristics are associated with differential effects on intradialytic microvascular tissue perfusion. (2025)](https://pubmed.ncbi.nlm.nih.gov/41675873/) — Using a rat model of hemodialysis, researchers compared how different types of dialysis filters affect blood flow in small vessels. They found that conventional high-flux filters caused a significant 25 percent reduction in tissue perfus...
- [Oral morphine pharmacokinetics in healthy children and the effect of genetic polymorphisms: An exploratory study. (2025)](https://pubmed.ncbi.nlm.nih.gov/41630937/) — This study explored how children's bodies process oral morphine and its active metabolites by measuring blood concentrations in healthy participants aged 5 to 17. Researchers found that the active metabolites of morphine remain in the sy...
- [Should AV Fistulas be Ligated Electively after Successful Kidney Transplantation: Commentary. (2025)](https://pubmed.ncbi.nlm.nih.gov/41433095/) — This commentary discusses the ongoing debate regarding whether a functioning arteriovenous fistula should be surgically closed after a patient receives a successful kidney transplant. The authors explore the potential benefits of closing... Topics: Kidney Transplantation, Dialysis Vascular Access, Cardiovascular Disease, Commentary / Editorial
- [Consensus-based Recommendations on the Management of Immunosuppression After Squamous Cell Carcinoma Diagnosis in Kidney Transplant Recipients: An International Delphi Consensus Statement. (2025)](https://pubmed.ncbi.nlm.nih.gov/41415033/) — An international panel of transplant nephrologists used a structured survey process to develop standardized recommendations for managing immunosuppression in kidney transplant recipients who develop skin cancer. The experts reached a con... Topics: Kidney Transplantation, Kidney Disease in Cancer
- [Outcomes of Adopting a Higher Versus Lower Concentration of Hemodialysate Magnesium as a Center-Wide Policy (Dial-Mag): A Clinical Research Protocol of a Pragmatic, Registry-Based, Cluster Randomized Trial. (2025)](https://pubmed.ncbi.nlm.nih.gov/41393273/) — This protocol describes an ongoing study across 137 Canadian hemodialysis centres to determine if using a higher concentration of magnesium in dialysis fluid reduces the risk of death, heart disease, and muscle cramps. Researchers are co... Topics: Hemodialysis, Cardiovascular Disease, Bone Health, Interventional Study, Pragmatic Trial, Administrative Data
- [Validating Recipients of Pediatric Solid Organ Transplant Using Administrative Healthcare Data. (2025)](https://pubmed.ncbi.nlm.nih.gov/41362119/) — Researchers compared records from a major pediatric transplant centre in Ontario to provincial health databases to determine if administrative data can accurately identify children who received organ transplants. They found that using sp... Topics: Kidney Transplantation, Health Systems, Observational Study, Administrative Data, Diagnostic Accuracy
- [Does Remote Monitoring Improve Time on Peritoneal Dialysis?: CON. (2025)](https://pubmed.ncbi.nlm.nih.gov/41348487/) — This publication presents a debate on whether remote monitoring technology effectively extends the amount of time patients can remain on peritoneal dialysis. The author argues against the position that remote monitoring provides a clear... Topics: Peritoneal Dialysis, Remote Monitoring and Care, Commentary / Editorial
- [Coronary Artery Disease and Intradialytic Myocardial Ischemia in Hemodialysis: An Exploratory Study Using Intradialytic Imaging. (2025)](https://pubmed.ncbi.nlm.nih.gov/41342048/) — Researchers used advanced imaging to study how hemodialysis affects blood flow to the heart muscle in thirteen patients with and without coronary artery disease. They found that dialysis caused a significant reduction in heart muscle per... Topics: Hemodialysis, Cardiovascular Disease, Observational Study, Advanced Imaging
- [A New Multidisciplinary Model of Glomerulonephritis Care in Ontario: A Descriptive Program Report. (2025)](https://pubmed.ncbi.nlm.nih.gov/41341628/) — In 2018, Ontario established a new multidisciplinary care model to provide standardized and timely treatment for patients with glomerulonephritis across the province. A review of nearly 7,000 patients treated under this model found that... Topics: Glomerular Disease, Health Systems, Observational Study, Administrative Data
- [Impact of Expanded Hemodialysis on Subjective Experience Using Dynamic Patient-Reported Outcome Measurement Tool. (2025)](https://pubmed.ncbi.nlm.nih.gov/41333100/) — Researchers in Ontario, Canada, studied whether a newer type of dialysis called expanded hemodialysis could improve the quality of life and symptom burden for patients compared to standard treatment. Using a specialized digital tool to t... Topics: Hemodialysis, Interventional Study, Patient-Reported Outcomes
- [Glucagon-like Peptide-1 Receptor Agonists and Risk of Major Adverse Cardiovascular Events in Patients With CKD. (2025)](https://pubmed.ncbi.nlm.nih.gov/41238166/) — This study compared the cardiovascular outcomes of patients with chronic kidney disease in Ontario who started taking either glucagon-like peptide-1 receptor agonists or dipeptidyl peptidase-4 inhibitors. Researchers found that those usi... Topics: Diabetes and Metabolism, Cardiovascular Disease, Chronic Kidney Disease, Observational Study, Administrative Data, Risk Estimation and Prognosis
- [Soluble urokinase plasminogen activator receptor and perioperative complications: a systematic review. (2025)](https://pubmed.ncbi.nlm.nih.gov/41233776/) — Researchers reviewed nineteen studies to determine if a blood marker called soluble urokinase plasminogen activator receptor can predict complications following surgery. The analysis found that higher levels of this marker are likely ass... Topics: Perioperative and Surgery, Acute Kidney Injury, Systematic Evidence Synthesis, Biomarker Development or Validation, Risk Estimation and Prognosis
- [Risk for Scrotal Surgery After Laparoscopic Donor Nephrectomy : A Population-Based Cohort Study. (2025)](https://pubmed.ncbi.nlm.nih.gov/41213151/) — Researchers in Ontario, Canada, found that men who donated a kidney through laparoscopic surgery had a significantly higher risk of requiring scrotal surgery later in life compared to men who did not donate. Over a 20-year period, nearly... Topics: Kidney Transplantation, Perioperative and Surgery, Observational Study, Administrative Data, Risk Estimation and Prognosis
- [Validity of the International Classification of Diseases, 10th Revision codes for lithium toxicity in adult patients at hospital admission: a cohort study in Canada. (2025)](https://pubmed.ncbi.nlm.nih.gov/41207790/) — Researchers in Ontario evaluated the accuracy of hospital diagnostic codes for identifying lithium toxicity by comparing them to actual blood laboratory results. The study found that while these codes were moderately effective at identif... Topics: Drug Safety, Observational Study, Administrative Data, Diagnostic Accuracy

## Data Sources
- PubMed (publications)
- ClinicalTrials.gov (trial metadata)
- OpenAlex (publication metadata)

## Sitemap
https://londonkidney.ca/sitemap.xml