Transversus Abdominis Plane Catheter Following Kidney Transplantation (KTAP)
NCT04786470Sponsor: Western University, CanadaEEphraim Tang
Actively Recruiting
About This Study
This phase III, randomized, double-blind, sham-controlled trial evaluates the efficacy of continuous transversus abdominis plane (TAP) catheter infusions for postoperative pain management in kidney transplant recipients. Investigators randomize patients to receive either a continuous infusion of ropivacaine or a saline sham via a surgically placed TAP catheter for 48 hours. Both cohorts receive a standardized multimodal analgesic regimen consisting of a PCA pump, acetaminophen, and gabapentin. The study aims to determine if regional local anesthetic delivery reduces opioid consumption and improves pain control compared to standard systemic analgesia alone in this surgical population.
Who Can Participate?
✓ Inclusion Criteria
- •Provision of signed and dated informed consent form
- •Stated willingness to comply with all study procedures and availability for the duration of the study
- •Male, female, non-binary gender, aged >18 years.
- •Undergoing a kidney transplant (deceased or living donor) as treatment for stage 5 chronic kidney disease (Glomerular filtration rate < 15ml/min) either on dialysis, or approaching dialysis
- •No history of allergy to any local anesthetic.
- •Agreement to adhere to Lifestyle Considerations (see section 5.3) throughout study duration
✗ Exclusion Criteria
- •Current use of opioid pain medications prior to kidney transplantation.
- •Known allergic reactions to components of any local anesthetic medication.
- •Prior local anesthetic systemic toxicity.
- •History of chronic pain undergoing current active treatment for the same.
- •Age <18 years (this analgesic approach has not been established in this population).
- •Unable or unwilling to use IV PCA pump for any reason (manual dexterity, cognitive impairment, patient choice etc.).
- •Multi-visceral transplantation.
- •Incision other than standard Gibson incision.
- •Unilateral or bilateral nephrectomy at time of kidney transplant.
- •Advanced liver disease.