Cardiac Tissue Sodium Assessment in CKD Patients Using Sodium MRI

NCT04848636Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Actively Recruiting

About This Study

This pilot exploratory study evaluates cardiac sodium deposition across the spectrum of renal impairment using sodium and proton MRI. Investigators compare approximately 150 participants, including hemodialysis patients, patients with various stages of CKD, and age-matched healthy controls. The study correlates cardiac sodium content with biomarkers of cardiac stress, fluid volume measured by bioimpedance spectroscopy, and MRI-derived measures of cardiac function and fibrosis. The primary objective is to determine if myocardial sodium retention relates to cardiac structural abnormalities and to establish a baseline for future interventional studies.

Who Can Participate?

✓ Inclusion Criteria

•Age greater than or equal to 18 years
•For patients on maintenance hemodialysis: more than 3 months duration of therapy
•For patients with CKD: evidence of kidney disease persisting > 3 months and no indications to start dialysis
•For healthy controls: lack of kidney disease, cardiovascular disease, diabetes, liver cirrhosis and peripheral edema

✗ Exclusion Criteria

•Pregnant, breastfeeding or intending pregnancy
•Contraindication to MRI scan
•Inability to tolerate MRI due to patient size and/or known history of claustrophobia.
•Mechanically implanted, electrically, or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, tattoos, shunt, surgical staples (including clips or metallic sutures and/or ear implants.)