Active, Not Recruiting
This study is ongoing but no longer accepting new participants.
Exercise and Cardiac Stunning During HD
About This Study
The TICKERS-HD trial evaluates the impact of a 12-week intradialytic cycling program on myocardial stunning in adults with end-stage kidney disease receiving chronic hemodialysis. Investigators utilize echocardiography to assess changes in regional wall motion abnormalities and hemodialysis-related symptoms during aerobic exercise. The study aims to determine if regular intradialytic exercise mitigates recurrent ischemic cardiac injury and improves functional status in this high-risk population. This intervention targets the reduction of cardiac failure and mortality associated with treatment-induced myocardial stunning.
Who Can Participate?
✓ Inclusion Criteria
- •Adults greater than or equal to 18 years old (no upper age limit); who are greater than; 3 months after starting maintenance hemodialysis
- •No expected change in dialysis modality, elective surgery or relocation outside of study site during the intervention period (16 weeks)
- •Assessed to be safe and able to exercise by the hemodialysis unit nephrologist
- •Able to communicate in English and provide written informed consent
- •Must be dialyzing thrice weekly
✗ Exclusion Criteria
- •Acute coronary syndrome in the past 3 months
- •Unstable arrhythmia
- •Shortness of breath at rest or with minimal activity (NYHA Class 4)
- •Symptomatic hypoglycemia (> 2x/week in week prior to enrolment)
- •Participating in clinical intradialytic cycling program in last 3 months (if a clinical program exists)