Sodium Deposition in Soft Tissues of Patients with Kidney Disease
Actively Recruiting
About This Study
This pilot study evaluates non-osmotic sodium deposition in the skin, muscle, and skeleton of patients with CKD stages 1-5, maintenance hemodialysis, peritoneal dialysis, and heart failure. Investigators utilize novel Na+ MRI of the lower leg to quantify tissue sodium content and compare findings against age- and sex-matched healthy controls. The study examines the association between these sodium stores, uremic symptomatology, and biochemical markers of metabolism and inflammation. Clinical assessments include symptom questionnaires, functional physical testing, echocardiography, and laboratory analysis of blood and urine. Participants undergo an initial assessment with potential follow-up visits over a two-year period to track changes in sodium deposition and clinical status.
Who Can Participate?
✓ Inclusion Criteria
- •Age greater than or equal to 6 years
- •For patients on maintenance hemodialysis or peritoneal dialysis: more than 3 months duration of therapy
- •For patients with CKD stage 1-5: CKD stage 1-5 and no indications to start dialysis
- •For heart failure patients: with or without renal dysfunction
- •For healthy controls: lack of kidney disease, heart failure, liver cirrhosis, and peripheral edema For subsequent visits (must meet 1 of the below indicators):
- •Change in dialysis prescription
- •Change in renal replacement therapy modality
- •Change in medication
- •Parathyroidectomy
- •Intervention added to or removed from dialysis (i.e. such as but not limited exercise, cooling, and ischemic preconditioning)
✗ Exclusion Criteria
- •Pregnant, breastfeeding or intending pregnancy
- •Unable to give consent or understand written information
- •Contraindication to MRI study