Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates (CARSK)
Transplant – eligibility and preparation · University of British Columbia
The CARSK trial evaluates whether eliminating routine, non-invasive coronary artery disease (CAD) screening after waitlist activation is non-inferior to standard periodic screening for preventing major adverse cardiac events. The study population consists of asymptomatic kidney transplant candidates with ESRD who have already undergone initial screening for waitlist entry. Participants are randomized to either no further CAD screening until transplantation or regular screening at annual intervals. Secondary outcomes include the rate of transplantation and the relative cost-effectiveness of each strategy. This trial addresses the lack of evidence supporting the current practice of repetitive cardiac testing in patients awaiting renal replacement therapy.