Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial
Perioperative care (non-transplant), Transplant – perioperative · Hamilton Health Sciences Corporation
The BRACKETS pilot trial is a multicentre, randomized controlled trial evaluating the feasibility and safety of prophylactic preoperative tranexamic acid (TXA) and desmopressin in patients with advanced CKD or AKI undergoing noncardiac surgery. Utilizing a partial factorial design, the study compares TXA versus placebo and desmopressin versus placebo to address the increased bleeding risk associated with impaired primary hemostasis in this population. The trial aims to provide preliminary efficacy data and pharmacokinetic profiles to inform dose selection for a larger international phase. Investigators seek to determine if these generic agents reduce perioperative bleeding complications in a high-risk cohort typically excluded from major surgical trials.