A Prospective Observational Study to Evaluate Changes in Body Composition and Physical Function Using Imaging in Participants With Type 2 Diabetes Initiating GLP-1 Receptor Agonist Therapy (REBUILD)
Pre-dialysis CKD, Peritoneal dialysis, Hemodialysis, Dialysis vascular access · Kristin Clemens
This prospective, single-arm study evaluates the impact of GLP-1RA or GLP-1RA/GIP agonists on muscle and bone health in 20 patients with type 2 diabetes. Investigators utilize advanced PET/CT imaging at baseline, 3, 6, and 12 months to quantify changes in intramuscular fat, bone blood flow, and glucose metabolism following medication initiation. The study also tracks longitudinal changes in physical function through grip strength, gait speed, and Timed Up and Go assessments. The primary objective is to characterize early markers of sarcopenia and bone fragility to assist in the development of clinical prediction tools for patients at high risk of frailty. Findings aim to guide the integration of bone-protecting therapies or physical therapy for patients prescribed semaglutide or tirzepatide.